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Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor

Electron Microscopy
2.1Å resolution
PDB entry 6x19 coloured by chain, front view.
PDB entry 6x19 coloured by chain, side view.
PDB entry 6x19 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 56842.69 Å2
Buried surface area: 12606.42 Å2
Dissociation area: 1,330.44 Å2
Dissociation energy (ΔGdiss): -0.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211233

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 100%)
  • Best match: P63092-4 (Residues: 1-395)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6x19, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6x19, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6x19, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6x19, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6x19, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6x19, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 58 amino acids
Theoretical weight: 6.38 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 5-62; Coverage: 82%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6x19, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6x19, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6x19, assembly 1, top view.
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Nanobody35
Chain: N
Length: 128 amino acids
Theoretical weight: 13.89 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
Nanobody35 in PDB entry 6x19, assembly 1, front view.
Nanobody35 in PDB entry 6x19, assembly 1, side view.
Nanobody35 in PDB entry 6x19, assembly 1, top view.
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Glucagon-like peptide 1 receptor
Chain: R
Length: 491 amino acids
Theoretical weight: 56.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P43220 (Residues: 24-463; Coverage: 100%)
Gene name: GLP1R
Pfam:
InterPro:
Glucagon-like peptide 1 receptor in PDB entry 6x19, assembly 1, front view.
Glucagon-like peptide 1 receptor in PDB entry 6x19, assembly 1, side view.
Glucagon-like peptide 1 receptor in PDB entry 6x19, assembly 1, top view.
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