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Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors

X-ray diffraction
2.513Å resolution
PDB entry 6x5j coloured by chain, front view.
PDB entry 6x5j coloured by chain, side view.
PDB entry 6x5j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor IXa complex
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Multimeric state: hetero dimer
Accessible surface area: 13065.66 Å2
Buried surface area: 4316.88 Å2
Dissociation area: 783.45 Å2
Dissociation energy (ΔGdiss): 0.96 kcal/mol
Dissociation entropy (TΔSdiss): 10.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133191
Complex Portal ID: CPX-4945

Macromolecules

Coagulation factor IXa heavy chain
Chain: A
Length: 235 amino acids
Theoretical weight: 26.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00740 (Residues: 227-461; Coverage: 54%)
Gene name: F9
Pfam: Trypsin
InterPro:
Coagulation factor IXa heavy chain in PDB entry 6x5j, assembly 1, front view.
Coagulation factor IXa heavy chain in PDB entry 6x5j, assembly 1, side view.
Coagulation factor IXa heavy chain in PDB entry 6x5j, assembly 1, top view.
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Coagulation factor IXa light chain
Chain: B
Length: 62 amino acids
Theoretical weight: 6.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00740 (Residues: 130-191; Coverage: 14%)
Gene name: F9
Pfam: Coagulation Factor Xa inhibitory site
Coagulation factor IXa light chain in PDB entry 6x5j, assembly 1, front view.
Coagulation factor IXa light chain in PDB entry 6x5j, assembly 1, side view.
Coagulation factor IXa light chain in PDB entry 6x5j, assembly 1, top view.
Molecule details ›

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