Function and Biology

NADase from Aspergillus fumigatus with trapped reaction products

Source organism: Aspergillus fumigatus Af293
Biochemical function: NADP+ nucleosidase activity
Biological process: not assigned
Cellular component: not assigned

EC 3.2.2.5: NAD(+) glycohydrolase

Reaction catalysed:
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide
Systematic name:
NAD(+) glycohydrolase
Alternative Name(s):
  • ADP-ribosyl cyclase
  • Beta-NAD(+) glycohydrolase
  • DPN hydrolase
  • DPNase
  • Diphosphopyridine nucleosidase
  • NAD glycohydrolase
  • NAD hydrolase
  • NAD nucleosidase
  • NAD(+) nucleosidase
  • NADase
  • Nga (gene name)
  • Nicotinamide adenine dinucleotide glycohydrolase
  • Nicotinamide adenine dinucleotide nucleosidase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF14021
Domain description: Tuberculosis necrotizing toxin
Occurring in:
  1. Conidial surface nicotinamide adenine dinucleotide glycohydrolase nadA
The deposited structure of PDB entry 6ygf contains 2 copies of Pfam domain PF14021 (Tuberculosis necrotizing toxin) in Conidial surface nicotinamide adenine dinucleotide glycohydrolase nadA. Showing 1 copy in chain B [auth A].

InterPro InterPro annotation
IPR025331
Domain description: Tuberculosis necrotizing toxin
Occurring in:
  1. Conidial surface nicotinamide adenine dinucleotide glycohydrolase nadA