› 6ytx

Electron Microscopy
6.23Å resolution

Cryo-EM structure of undecameric human CALHM6 in the presence of Ca2+

Released:
DOI: 10.2210/pdb6ytx/pdb
PDB entry 6ytx coloured by chain, front view.
PDB entry 6ytx coloured by chain, side view.
PDB entry 6ytx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Drożdżyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
Elife 9 (2020)
PMID: 32374262
Related structures: EMD-10925

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo undecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 6 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 315 amino acids
Theoretical weight: 34.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5R3K3 (Residues: 1-315; Coverage: 100%)
Gene names: C6orf187, CALHM6, FAM26F
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.23Å
Relevant EMDB volumes: EMD-10925
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Taste transduction and channel synapses in taste buds.
Taruno et al. (2021)
1 more

2 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
1 more