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Cryo-EM structure of undecameric human CALHM6 in the presence of Ca2+

Electron Microscopy
6.23Å resolution
PDB entry 6ytx coloured by chain, front view.
PDB entry 6ytx coloured by chain, side view.
PDB entry 6ytx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo undecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium homeostasis modulator protein 6
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Multimeric state: homo undecamer
Accessible surface area: 153933.63 Å2
Buried surface area: 53816.38 Å2
Dissociation area: 26,908.19 Å2
Dissociation energy (ΔGdiss): 417.54 kcal/mol
Dissociation entropy (TΔSdiss): 149.5 kcal/mol
Symmetry number: 11
PDBe Complex ID: PDB-CPX-177778

Macromolecules

Calcium homeostasis modulator protein 6
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 315 amino acids
Theoretical weight: 34.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5R3K3 (Residues: 1-315; Coverage: 100%)
Gene names: C6orf187, CALHM6, FAM26F
Pfam: Calcium homeostasis modulator
InterPro: Calcium homeostasis modulator family
Calcium homeostasis modulator protein 6 in PDB entry 6ytx, assembly 1, front view.
Calcium homeostasis modulator protein 6 in PDB entry 6ytx, assembly 1, side view.
Calcium homeostasis modulator protein 6 in PDB entry 6ytx, assembly 1, top view.
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