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Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II)

Electron Microscopy
3.2Å resolution
PDB entry 6z2x coloured by chain, front view.
PDB entry 6z2x coloured by chain, side view.
PDB entry 6z2x coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATR-ATRIP DNA damage-sensing kinase complex
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Multimeric state: hetero tetramer
Accessible surface area: 225846.53 Å2
Buried surface area: 39590.85 Å2
Dissociation area: 4,197.42 Å2
Dissociation energy (ΔGdiss): 32.97 kcal/mol
Dissociation entropy (TΔSdiss): 19.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153548
Complex Portal ID: CPX-3621

Macromolecules

DNA damage checkpoint protein LCD1
Chains: C, D
Length: 747 amino acids
Theoretical weight: 86.53 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q04377 (Residues: 1-747; Coverage: 100%)
Gene names: DDC2, LCD1, PIE1, YDR499W
Pfam: DNA damage checkpoint protein
InterPro: DNA damage checkpoint protein, Lcd1
DNA damage checkpoint protein LCD1 in PDB entry 6z2x, assembly 1, front view.
DNA damage checkpoint protein LCD1 in PDB entry 6z2x, assembly 1, side view.
DNA damage checkpoint protein LCD1 in PDB entry 6z2x, assembly 1, top view.
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Serine/threonine-protein kinase MEC1
Chains: E, F
Length: 2368 amino acids
Theoretical weight: 273.65 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38111 (Residues: 1-2368; Coverage: 100%)
Gene names: ESR1, MEC1, SAD3, YBR1012, YBR136W
Pfam:
InterPro:
Serine/threonine-protein kinase MEC1 in PDB entry 6z2x, assembly 1, front view.
Serine/threonine-protein kinase MEC1 in PDB entry 6z2x, assembly 1, side view.
Serine/threonine-protein kinase MEC1 in PDB entry 6z2x, assembly 1, top view.
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