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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F5

X-ray diffraction
1.12Å resolution
PDB entry 6zel coloured by chain, front view.
PDB entry 6zel coloured by chain, side view.
PDB entry 6zel coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 7658.73 Å2
Buried surface area: 490.23 Å2
Dissociation area: 75.28 Å2
Dissociation energy (ΔGdiss): -1.64 kcal/mol
Dissociation entropy (TΔSdiss): -0.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112

Macromolecules

Bromodomain-containing protein 4
Chain: AAA
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Pfam: Bromodomain
InterPro:
Bromodomain-containing protein 4 in PDB entry 6zel, assembly 1, front view.
Bromodomain-containing protein 4 in PDB entry 6zel, assembly 1, side view.
Bromodomain-containing protein 4 in PDB entry 6zel, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O60885  
1127102030405060708090100110120
 
50100
UniProt
O60885
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