› › Function and Biology

Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose

Source organism: Homo sapiens
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 3.2.1.130: Glycoprotein endo-alpha-1,2-mannosidase

Reaction catalysed:
GlcMan(9)GlcNAc(2)-[protein] + H(2)O = Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,2)) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose
Systematic name:
Glycoprotein glucosylmannohydrolase (configuration-retaining)
Alternative Name(s):
  • Endo-alpha-D-mannosidase
  • Endo-alpha-mannosidase
  • Endomannosidase
  • Glucosyl mannosidase
  • Glucosylmannosidase
  • Glycoprotein glucosylmannohydrolase
  • MANEA (gene name)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF16317
Domain description: Glycosyl hydrolase family 99
Occurring in:
  1. Glycoprotein endo-alpha-1,2-mannosidase
The deposited structure of PDB entry 6zfn contains 1 copy of Pfam domain PF16317 (Glycosyl hydrolase family 99) in Glycoprotein endo-alpha-1,2-mannosidase. Showing 1 copy in chain A [auth AAA].

InterPro InterPro annotations
IPR026071
Domain description: Glycosyl hydrolase family 99
Occurring in:
  1. Glycoprotein endo-alpha-1,2-mannosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Glycoprotein endo-alpha-1,2-mannosidase

Quick links