› 6zg1

Electron Microscopy
3.77Å resolution

SARM1 SAM1-2 domains

Released:
DOI: 10.2210/pdb6zg1/pdb
PDB entry 6zg1 coloured by chain, front view.
PDB entry 6zg1 coloured by chain, side view.
PDB entry 6zg1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny M, Guez-Haddad J, Khazma T, Yaron A, Dessau M, Shkolnisky Y, Mim C, Isupov MN, Zalk R, Hons M, Opatowsky Y
OpenAccess logo Elife 9 (2020)
PMID: 33185189
Related structures: EMD-11191

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 164 amino acids
Theoretical weight: 18.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6SZW1 (Residues: 387-548; Coverage: 22%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains: SAM domain (Sterile alpha motif)

Ligands and Environments

4 bound ligands:
Ligand EDO 17 x EDO
Ligand BME 8 x BME
Ligand PEG 2 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.77Å
Relevant EMDB volumes: EMD-11191
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Evolving concepts in NAD+ metabolism.
Chini et al. (2021)
15 more

1 mention without citation

Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny et al. (2020)