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SARM1 SAM1-2 domains

Electron Microscopy
3.77Å resolution
PDB entry 6zg1 coloured by chain, front view.
PDB entry 6zg1 coloured by chain, side view.
PDB entry 6zg1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NAD(+) hydrolase SARM1
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Multimeric state: homo octamer
Accessible surface area: 56789.5 Å2
Buried surface area: 19010.33 Å2
Dissociation area: 7,081.78 Å2
Dissociation energy (ΔGdiss): -56.52 kcal/mol
Dissociation entropy (TΔSdiss): 89.62 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-180347

Macromolecules

NAD(+) hydrolase SARM1
Chains: A, B, C, D, E, F, G, H
Length: 164 amino acids
Theoretical weight: 18.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6SZW1 (Residues: 387-548; Coverage: 22%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Pfam: SAM domain (Sterile alpha motif)
InterPro:
NAD(+) hydrolase SARM1 in PDB entry 6zg1, assembly 1, front view.
NAD(+) hydrolase SARM1 in PDB entry 6zg1, assembly 1, side view.
NAD(+) hydrolase SARM1 in PDB entry 6zg1, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6SZW1  
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