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Cryo-EM structure of mature Spondweni virus

Source organism: Spondweni virus
Biochemical function: protein dimerization activity
Biological process: viral life cycle
Cellular component: not assigned

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.91: Flavivirin

Reaction catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Alternative Name(s):
  • NS2B-3 proteinase
  • Yellow fever virus (flavivirus) protease
  • Yellow fever virus protease

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01004
Domain description: Flavivirus envelope glycoprotein M
Occurring in:
  1. Genome polyprotein
The deposited structure of PDB entry 6zqv contains 3 copies of Pfam domain PF01004 (Flavivirus envelope glycoprotein M) in Genome polyprotein. Showing 1 copy in chain B.

PF21659
Domain description: Flavivirus envelope glycoprotein E, stem/anchor domain
Occurring in:
  1. Genome polyprotein

PF02832
Domain description: Flavivirus glycoprotein, immunoglobulin-like domain
Occurring in:
  1. Genome polyprotein
The deposited structure of PDB entry 6zqv contains 3 copies of Pfam domain PF02832 (Flavivirus glycoprotein, immunoglobulin-like domain) in Genome polyprotein. Showing 1 copy in chain A.

PF00869
Domain description: Flavivirus glycoprotein, central and dimerisation domains
Occurring in:
  1. Genome polyprotein
The deposited structure of PDB entry 6zqv contains 3 copies of Pfam domain PF00869 (Flavivirus glycoprotein, central and dimerisation domains) in Genome polyprotein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027287
Domain description: Glycoprotein E, immunoglobulin-like domain, flavivirus
Occurring in:
  1. Genome polyprotein
IPR000069
Domain description: Envelope glycoprotein M, flavivirus
Occurring in:
  1. Genome polyprotein
IPR038302
Domain description: Envelope glycoprotein M superfamily, flavivirus
Occurring in:
  1. Genome polyprotein
IPR038345
Domain description: Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily
Occurring in:
  1. Genome polyprotein
IPR026470
Domain description: Flavivirus envelope glycoprotein E, Stem/Anchor domain
Occurring in:
  1. Genome polyprotein
IPR000336
Domain description: Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
Occurring in:
  1. Genome polyprotein
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Genome polyprotein
IPR013755
Domain description: Flaviviral glycoprotein E, central domain, subdomain 1
Occurring in:
  1. Genome polyprotein
IPR013756
Domain description: Flaviviral glycoprotein E, central domain, subdomain 2
Occurring in:
  1. Genome polyprotein
IPR038055
Domain description: Flaviviral glycoprotein E, dimerisation domain
Occurring in:
  1. Genome polyprotein
IPR036253
Domain description: Flavivirus glycoprotein, central and dimerisation domain superfamily
Occurring in:
  1. Genome polyprotein
IPR011998
Domain description: Envelope glycoprotein E, central and dimerisation domain, flavivirus
Occurring in:
  1. Genome polyprotein

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