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Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate

X-ray diffraction
2Å resolution
PDB entry 6zs4 coloured by chain, front view.
PDB entry 6zs4 coloured by chain, side view.
PDB entry 6zs4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein polybromo-1
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Multimeric state: monomeric
Accessible surface area: 6766.8 Å2
Buried surface area: 130.06 Å2
Dissociation area: 65.03 Å2
Dissociation energy (ΔGdiss): -1.05 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-183177

Macromolecules

Protein polybromo-1
Chain: A
Length: 124 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 645-766; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Pfam: Bromodomain
InterPro:
Protein polybromo-1 in PDB entry 6zs4, assembly 1, front view.
Protein polybromo-1 in PDB entry 6zs4, assembly 1, side view.
Protein polybromo-1 in PDB entry 6zs4, assembly 1, top view.
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