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Crystal structure of human Brachyury G177D variant in complex with Afatinib

X-ray diffraction
1.95Å resolution
PDB entry 6zu8 coloured by chain, front view.
PDB entry 6zu8 coloured by chain, side view.
PDB entry 6zu8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: T-box transcription factor T
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Multimeric state: monomeric
Accessible surface area: 10090.95 Å2
Buried surface area: 96.32 Å2
Dissociation area: 48.16 Å2
Dissociation energy (ΔGdiss): 29.38 kcal/mol
Dissociation entropy (TΔSdiss): -0.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127349

Macromolecules

T-box transcription factor T
Chain: A
Length: 192 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-224; Coverage: 42%)
Gene names: T, TBXT
Pfam: T-box
InterPro:
Brachyury protein in PDB entry 6zu8, assembly 1, front view.
Brachyury protein in PDB entry 6zu8, assembly 1, side view.
Brachyury protein in PDB entry 6zu8, assembly 1, top view.
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