› 6zya

Electron Microscopy
3.5Å resolution

Extended human uromodulin filament core at 3.5 A resolution

Released:
DOI: 10.2210/pdb6zya/pdb
PDB entry 6zya coloured by chain, front view.
PDB entry 6zya coloured by chain, side view.
PDB entry 6zya coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Stanisich JJ, Zyla DS, Afanasyev P, Xu J, Kipp A, Olinger E, Devuyst O, Pilhofer M, Boehringer D, Glockshuber R
OpenAccess logo Elife 9 (2020)
PMID: 32815518
Related structures: EMD-11388

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Uromodulin Chain: A
Molecule details ›
Chain: A
Length: 640 amino acids
Theoretical weight: 69.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07911 (Residues: 1-640; Coverage: 100%)
Gene name: UMOD
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-11388

Quick links

Citations

9 review citations

Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy.
Chua et al. (2022)
8 more