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Notum_Ghrelin complex

X-ray diffraction
2.19Å resolution
PDB entry 6zyf coloured by chain, front view.
PDB entry 6zyf coloured by chain, side view.
PDB entry 6zyf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Palmitoleoyl-protein carboxylesterase NOTUM
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Multimeric state: monomeric
Accessible surface area: 15573.23 Å2
Buried surface area: 254.25 Å2
Dissociation area: 127.13 Å2
Dissociation energy (ΔGdiss): -4.98 kcal/mol
Dissociation entropy (TΔSdiss): 2.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180133
Assembly 2 (preferred)
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Assembly Name: Palmitoleoyl-protein carboxylesterase NOTUM
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Multimeric state: monomeric
Accessible surface area: 15402.2 Å2
Buried surface area: 707.88 Å2
Dissociation area: 104.15 Å2
Dissociation energy (ΔGdiss): -1.98 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180133

Macromolecules

Palmitoleoyl-protein carboxylesterase NOTUM
Chains: A, B
Length: 383 amino acids
Theoretical weight: 43.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P988 (Residues: 81-451; Coverage: 78%)
Gene names: NOTUM, OK/SW-CL.30
Pfam: Pectinacetylesterase
InterPro: Pectinacetylesterase/NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM in PDB entry 6zyf, assembly 2, front view.
Palmitoleoyl-protein carboxylesterase NOTUM in PDB entry 6zyf, assembly 2, side view.
Palmitoleoyl-protein carboxylesterase NOTUM in PDB entry 6zyf, assembly 2, top view.
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