7cz5

Electron Microscopy
2.6Å resolution

Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-208390 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Growth hormone-releasing hormone receptor Chain: R
Molecule details ›
Chain: R
Length: 556 amino acids
Theoretical weight: 61.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02643 (Residues: 23-405; Coverage: 96%)
Gene name: GHRHR
Sequence domains:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 100%)
  • Best match: P63092-4 (Residues: 1-395)
Gene names: GNAS, GNAS1, GSP
Sequence domains: G-protein alpha subunit
Somatoliberin Chain: P
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Nanobody35 Chain: N

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-30505
Expression systems:
  • Spodoptera frugiperda
  • Not provided
  • Escherichia coli