Structure analysis

Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex

Electron Microscopy
2.6Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 46054.97 Å2
Buried surface area: 16405.09 Å2
Dissociation area: 1,307.33 Å2
Dissociation energy (ΔGdiss): -0.39 kcal/mol
Dissociation entropy (TΔSdiss): 12.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208390

Macromolecules

Chain: R
Length: 556 amino acids
Theoretical weight: 61.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
155650100150200250300350400450500550
 
200400HMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRGSSGGGGSGGGGSSGVFTLEDFVGDWEQTAAYNLDQVLEQGGVSSLLQNLAVSVTPIQRIVRSGENALKIDIHVIIPYEGLSADQMAQIEEVFKVVYPVDDHHFKVILPYGTLVIDGVTPNMLNYFGRPYEGIAVFDGKKITVTGTLWNGNKIIDERLITPDGSMLFRVTINS
UniProt
Q02643
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Variants

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Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
139450100150200250300350
 
100200300MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKNTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQAALKLFDSIWNNKWLRDTSVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
UniProt
P63092
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation

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Chain: P
Length: 44 amino acids
Theoretical weight: 5.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
144510152025303540
 
2040YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL
UniProt
P01286
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation

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Chain: B
Length: 400 amino acids
Theoretical weight: 43.71 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
140050100150200250300350400
 
100200300400MHHHHHHSSGLVPRGSHMASHHHHHHHHHHGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWNGSSGGGGSGGGGSSGVSGWRLFKKIS
UniProt
P54311
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation

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Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
171510152025303540455055606570
 
204060MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
UniProt
P63212
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation

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Chain: N
Length: 126 amino acids
Theoretical weight: 13.71 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
1126102030405060708090100110120
 
50100QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTV
Chains
Chain F (auth N)
Domains
Secondary structure
Interaction interfaces
Sequence conservation

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