› 7mbr

Electron Microscopy

Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (apo state)

Released:
DOI: 10.2210/pdb7mbr/pdb
PDB entry 7mbr coloured by chain, front view.
PDB entry 7mbr coloured by chain, side view.
PDB entry 7mbr coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Ruan Z, Haley E, Orozco IJ, Sabat M, Myers R, Roth R, Du J, Lü W
Nat Struct Mol Biol 28 604-613 (2021)
PMID: 34168372
Related structures: EMD-23744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197446 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1165 amino acids
Theoretical weight: 132.8 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: S5UH55 (Residues: 1-1165; Coverage: 100%)
Gene name: trpm5
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 4 x NAG
Ligand YUV 4 x YUV
Ligand YUY 4 x YUY
No modified residues

Experiments and Validation Details

Entry percentile scores
Relevant EMDB volumes: EMD-23744
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
6 more

1 mention without citation

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
Ruan et al. (2021)