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Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (apo state)

Electron Microscopy
PDB entry 7mbr coloured by chain, front view.
PDB entry 7mbr coloured by chain, side view.
PDB entry 7mbr coloured by chain, top view.
Source organism: Danio rerio
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transient receptor potential cation channel subfamily M member 5
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Multimeric state: homo tetramer
Accessible surface area: 167506.82 Å2
Buried surface area: 29196.87 Å2
Dissociation area: 14,280.45 Å2
Dissociation energy (ΔGdiss): 225.28 kcal/mol
Dissociation entropy (TΔSdiss): 54.12 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-197446

Macromolecules

Transient receptor potential cation channel subfamily M member 5
Chains: A, B, C, D
Length: 1165 amino acids
Theoretical weight: 132.8 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: S5UH55 (Residues: 1-1165; Coverage: 100%)
Gene name: trpm5
Pfam:
InterPro:
Transient receptor potential cation channel subfamily M member 5 in PDB entry 7mbr, assembly 1, front view.
Transient receptor potential cation channel subfamily M member 5 in PDB entry 7mbr, assembly 1, side view.
Transient receptor potential cation channel subfamily M member 5 in PDB entry 7mbr, assembly 1, top view.
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