Structure analysis

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A272

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 64170.89 Å2
Buried surface area: 4449.85 Å2
Dissociation area: 2,107.94 Å2
Dissociation energy (ΔGdiss): 5.72 kcal/mol
Dissociation entropy (TΔSdiss): 16 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-180439
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 65174.76 Å2
Buried surface area: 4416.93 Å2
Dissociation area: 2,091.49 Å2
Dissociation energy (ΔGdiss): 12.83 kcal/mol
Dissociation entropy (TΔSdiss): 16.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-180439

Macromolecules

Chains: A, B, C
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Pfam:
InterPro:

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