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Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Source organisms:
Biochemical function: ABC-type transporter activity
Biological process: regulation of chloride transport
Cellular component: external side of apical plasma membrane

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EC 7.6.2.2: ABC-type xenobiotic transporter

Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
  • ATP phosphohydrolase (steroid-exporting)
  • MDR protein
  • Multidrug-resistance protein
  • P-glycoprotein
  • PDR protein
  • Pleiotropic-drug-resistance protein
  • Steroid-transporting ATPase
  • Xenobiotic-transporting ATPase

EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 7a6e contains 2 copies of Pfam domain PF00005 (ABC transporter) in ATP-dependent translocase ABCB1. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. ATP-dependent translocase ABCB1
The deposited structure of PDB entry 7a6e contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in ATP-dependent translocase ABCB1. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. MRK16 Fab-fragment light chain
  2. MRK16 Fab-fragment heavy chain
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-dependent translocase ABCB1
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. MRK16 Fab-fragment light chain
IPR039421
Domain description: Type 1 protein exporter
Occurring in:
  1. ATP-dependent translocase ABCB1

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