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Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Electron Microscopy
3.6Å resolution
PDB entry 7a6e coloured by chain, front view.
PDB entry 7a6e coloured by chain, side view.
PDB entry 7a6e coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-dependent translocase ABCB1 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 71072.46 Å2
Buried surface area: 11967.14 Å2
Dissociation area: 807.57 Å2
Dissociation energy (ΔGdiss): -6.88 kcal/mol
Dissociation entropy (TΔSdiss): 14.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209352

Macromolecules

ATP-dependent translocase ABCB1
Chain: A
Length: 1280 amino acids
Theoretical weight: 141.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08183 (Residues: 1-1280; Coverage: 100%)
Gene names: ABCB1, MDR1, PGY1
Pfam:
InterPro:
ATP-dependent translocase ABCB1 in PDB entry 7a6e, assembly 1, front view.
ATP-dependent translocase ABCB1 in PDB entry 7a6e, assembly 1, side view.
ATP-dependent translocase ABCB1 in PDB entry 7a6e, assembly 1, top view.
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MRK16 Fab-fragment light chain
Chain: B
Length: 219 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
InterPro:
MRK16 Fab-fragment light chain in PDB entry 7a6e, assembly 1, front view.
MRK16 Fab-fragment light chain in PDB entry 7a6e, assembly 1, side view.
MRK16 Fab-fragment light chain in PDB entry 7a6e, assembly 1, top view.
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MRK16 Fab-fragment heavy chain
Chain: C
Length: 218 amino acids
Theoretical weight: 23.42 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
InterPro:
MRK16 Fab-fragment heavy chain in PDB entry 7a6e, assembly 1, front view.
MRK16 Fab-fragment heavy chain in PDB entry 7a6e, assembly 1, side view.
MRK16 Fab-fragment heavy chain in PDB entry 7a6e, assembly 1, top view.
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