› › Structure analysis

HAd7 knob in complex with 3 EC2-EC3 modules of DSG-2

Electron Microscopy
3.1Å resolution
PDB entry 7agf coloured by chain, front view.
PDB entry 7agf coloured by chain, side view.
PDB entry 7agf coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fiber protein and Desmoglein-2
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Multimeric state: hetero hexamer
Accessible surface area: 56384.4 Å2
Buried surface area: 12403.52 Å2
Dissociation area: 3,206.9 Å2
Dissociation energy (ΔGdiss): -2.36 kcal/mol
Dissociation entropy (TΔSdiss): 42.01 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-147230

Macromolecules

Fiber protein
Chains: A, B, C
Length: 213 amino acids
Theoretical weight: 23.49 KDa
Source organism: Human adenovirus 7
Expression system: Escherichia coli
UniProt:
  • Canonical: P15141 (Residues: 135-343; Coverage: 61%)
Gene name: L5
Pfam: Adenoviral fibre protein (knob domain)
InterPro:
Fiber protein in PDB entry 7agf, assembly 1, front view.
Fiber protein in PDB entry 7agf, assembly 1, side view.
Fiber protein in PDB entry 7agf, assembly 1, top view.
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Desmoglein-2
Chains: D, E, F
Length: 243 amino acids
Theoretical weight: 27.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14126 (Residues: 149-386; Coverage: 22%)
Gene names: CDHF5, DSG2
Pfam: Cadherin domain
InterPro:
Desmoglein-2 in PDB entry 7agf, assembly 1, front view.
Desmoglein-2 in PDB entry 7agf, assembly 1, side view.
Desmoglein-2 in PDB entry 7agf, assembly 1, top view.
Molecule details ›

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