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Inhibitory complex of human meprin beta with mouse fetuin-B.

Source organisms:
Biochemical function: cysteine-type endopeptidase inhibitor activity
Biological process: proteolysis
Cellular component: extracellular space

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EC 3.4.24.63: Meprin B

Reaction catalysed:
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His(5)-|-Leu-, -Leu(6)-|-Cys-, -Ala(14)-|-Leu- and -Cys(19)-|-Gly- bonds in insulin B chain.
Alternative Name(s):
  • Meprin-b

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00031
Domain description: Cystatin domain
Occurring in:
  1. Fetuin-B
The deposited structure of PDB entry 7auw contains 4 copies of Pfam domain PF00031 (Cystatin domain) in Fetuin-B. Showing 2 copies in chain B.

PF22486
Domain description: MATH domain
Occurring in:
  1. Meprin A subunit beta
The deposited structure of PDB entry 7auw contains 2 copies of Pfam domain PF22486 (MATH domain) in Meprin A subunit beta. Showing 1 copy in chain A.

PF00629
Domain description: MAM domain, meprin/A5/mu
Occurring in:
  1. Meprin A subunit beta
The deposited structure of PDB entry 7auw contains 2 copies of Pfam domain PF00629 (MAM domain, meprin/A5/mu) in Meprin A subunit beta. Showing 1 copy in chain A.

PF01400
Domain description: Astacin (Peptidase family M12A)
Occurring in:
  1. Meprin A subunit beta
The deposited structure of PDB entry 7auw contains 2 copies of Pfam domain PF01400 (Astacin (Peptidase family M12A)) in Meprin A subunit beta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000998
Domain description: MAM domain
Occurring in:
  1. Meprin A subunit beta
IPR001506
Domain description: Peptidase M12A
Occurring in:
  1. Meprin A subunit beta
IPR000010
Domain description: Cystatin domain
Occurring in:
  1. Fetuin-B
IPR001363
Domain description: Proteinase inhibitor I25C, fetuin, conserved site
Occurring in:
  1. Fetuin-B
IPR046350
Domain description: Cystatin superfamily
Occurring in:
  1. Fetuin-B
IPR025764
Domain description: Fetuin-B-type cystatin domain
Occurring in:
  1. Fetuin-B
IPR002083
Domain description: MATH/TRAF domain
Occurring in:
  1. Meprin A subunit beta
IPR008974
Domain description: TRAF-like
Occurring in:
  1. Meprin A subunit beta
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Meprin A subunit beta
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Meprin A subunit beta
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Meprin A subunit beta

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