PDB 7avi biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Son of sevenless homolog 1
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Multimeric state: monomeric

Accessible surface area: 25031.3 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-170560

$Monomeric assembly 1 of PDB entry 7avi coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7avi coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7avi coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Son of sevenless homolog 1
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Multimeric state: monomeric

Accessible surface area: 25069.94 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-170560

$Monomeric assembly 2 of PDB entry 7avi coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7avi coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7avi coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Son of sevenless homolog 1;</li> <li class='image_legend_li'>1 copy of 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Son of sevenless homolog 1

Chains: A, B
Length: 487 amino acids
Theoretical weight: 57.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: Q07889 (Residues: 564-1049; Coverage: 37%)

Gene name: SOS1
Pfam:

RasGEF N-terminal motif
RasGEF domain

InterPro:

Ras guanine nucleotide exchange factor domain superfamily
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras guanine-nucleotide exchange factor, conserved site

Son of sevenless homolog 1 in PDB entry 7avi, assembly 1, front view.

Son of sevenless homolog 1 in PDB entry 7avi, assembly 1, side view.

Son of sevenless homolog 1 in PDB entry 7avi, assembly 1, top view.

FASTA Sequence


    >pdb|7avi|A B

GEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT

PDBe-KB: UniProt Coverage View: Q07889

Molecule details ›

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FASTA (Protein chains A, B)
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Updated mmCIF file
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PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST Q07889 (UniProt)

Protein Data Bank in Europe

Crystal structure of SOS1 in complex with compound 2

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 7avi › Structure analysis

Crystal structure of SOS1 in complex with compound 2

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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7avi › Structure analysis