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MEK1 in complex with compound 23

X-ray diffraction
1.7Å resolution
PDB entry 7b9l coloured by chain, front view.
PDB entry 7b9l coloured by chain, side view.
PDB entry 7b9l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dual specificity mitogen-activated protein kinase kinase 1
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Multimeric state: monomeric
Accessible surface area: 14598.98 Å2
Buried surface area: 1298.98 Å2
Dissociation area: 63.64 Å2
Dissociation energy (ΔGdiss): 0.27 kcal/mol
Dissociation entropy (TΔSdiss): 0.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169744
Assembly 2
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Assembly Name: Dual specificity mitogen-activated protein kinase kinase 1
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Multimeric state: monomeric
Accessible surface area: 13967.52 Å2
Buried surface area: 1012.21 Å2
Dissociation area: 68.65 Å2
Dissociation energy (ΔGdiss): 11.46 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169744

Macromolecules

Dual specificity mitogen-activated protein kinase kinase 1
Chains: A, B
Length: 326 amino acids
Theoretical weight: 36.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02750 (Residues: 37-263, 308-383; Coverage: 77%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7b9l, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7b9l, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7b9l, assembly 1, top view.
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