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The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate

Electron Microscopy
3.8Å resolution
PDB entry 7bg9 coloured by chain, front view.
PDB entry 7bg9 coloured by chain, side view.
PDB entry 7bg9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 99609.83 Å2
Buried surface area: 19800.75 Å2
Dissociation area: 927.79 Å2
Dissociation energy (ΔGdiss): 8.29 kcal/mol
Dissociation entropy (TΔSdiss): 13.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-109984

Macromolecules

Telomerase reverse transcriptase
Chain: A
Length: 1332 amino acids
Theoretical weight: 149.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14746 (Residues: 1-1132; Coverage: 100%)
Gene names: EST2, TCS1, TERT, TRT
Pfam:
InterPro:
Telomerase reverse transcriptase in PDB entry 7bg9, assembly 1, front view.
Telomerase reverse transcriptase in PDB entry 7bg9, assembly 1, side view.
Telomerase reverse transcriptase in PDB entry 7bg9, assembly 1, top view.
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Histone H2B
Chain: M
Length: 166 amino acids
Theoretical weight: 18.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B4DR52 (Residues: 1-166; Coverage: 100%)
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
Histone H2B in PDB entry 7bg9, assembly 1, front view.
Histone H2B in PDB entry 7bg9, assembly 1, side view.
Histone H2B in PDB entry 7bg9, assembly 1, top view.
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Histone H2A type 1
Chain: L
Length: 130 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0S8 (Residues: 1-130; Coverage: 100%)
Gene names: H2AC11, H2AC13, H2AC15, H2AC16, H2AC17, H2AFC, H2AFD, H2AFI, H2AFN, H2AFP, HIST1H2AG, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM
Pfam:
InterPro:
Histone H2A type 1 in PDB entry 7bg9, assembly 1, front view.
Histone H2A type 1 in PDB entry 7bg9, assembly 1, side view.
Histone H2A type 1 in PDB entry 7bg9, assembly 1, top view.
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DNA chain N
Name: DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3')
Representative chains: N
Length: 18 nucleotides
Theoretical weight: 5.51 KDa
DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3') in PDB entry 7bg9, assembly 1, front view.
DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3') in PDB entry 7bg9, assembly 1, side view.
DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3') in PDB entry 7bg9, assembly 1, top view.
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RNA chain B
Name: RNA (256-MER)
Representative chains: B
Length: 451 nucleotides
Theoretical weight: 145.48 KDa
Rfam: Vertebrate telomerase RNA
RNA (256-MER) in PDB entry 7bg9, assembly 1, front view.
RNA (256-MER) in PDB entry 7bg9, assembly 1, side view.
RNA (256-MER) in PDB entry 7bg9, assembly 1, top view.
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