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BAZ2A bromodomain in complex with GSK2801 chemical probe

X-ray diffraction
1.3Å resolution
PDB entry 7bl9 coloured by chain, front view.
PDB entry 7bl9 coloured by chain, side view.
PDB entry 7bl9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain adjacent to zinc finger domain protein 2A
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Multimeric state: monomeric
Accessible surface area: 6345.2 Å2
Buried surface area: 178.78 Å2
Dissociation area: 89.39 Å2
Dissociation energy (ΔGdiss): -2.91 kcal/mol
Dissociation entropy (TΔSdiss): 0.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193785

Macromolecules

Bromodomain adjacent to zinc finger domain protein 2A
Chain: A
Length: 105 amino acids
Theoretical weight: 12.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF9 (Residues: 1796-1898; Coverage: 5%)
Gene names: BAZ2A, KIAA0314, TIP5
Pfam: Bromodomain
InterPro:
Bromodomain adjacent to zinc finger domain protein 2A in PDB entry 7bl9, assembly 1, front view.
Bromodomain adjacent to zinc finger domain protein 2A in PDB entry 7bl9, assembly 1, side view.
Bromodomain adjacent to zinc finger domain protein 2A in PDB entry 7bl9, assembly 1, top view.
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