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Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol

Source organism: Mycolicibacterium smegmatis MC2 155
Biochemical function: arabinosyltransferase activity
Biological process: Actinobacterium-type cell wall biogenesis
Cellular component: plasma membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF14896
Domain description: EmbC C-terminal domain
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF14896 (EmbC C-terminal domain) in Probable arabinosyltransferase B. Showing 1 copy in chain A.
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF14896 (EmbC C-terminal domain) in Probable arabinosyltransferase A. Showing 1 copy in chain B.

PF04602
Domain description: Mycobacterial cell wall arabinan synthesis protein
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF04602 (Mycobacterial cell wall arabinan synthesis protein) in Probable arabinosyltransferase B. Showing 1 copy in chain A.
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF04602 (Mycobacterial cell wall arabinan synthesis protein) in Probable arabinosyltransferase A. Showing 1 copy in chain B.

PF17689
Domain description: Arabinosyltransferase concanavalin like domain
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF17689 (Arabinosyltransferase concanavalin like domain) in Probable arabinosyltransferase B. Showing 1 copy in chain A.
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF17689 (Arabinosyltransferase concanavalin like domain) in Probable arabinosyltransferase A. Showing 1 copy in chain B.

PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Meromycolate extension acyl carrier protein
The deposited structure of PDB entry 7bvc contains 1 copy of Pfam domain PF00550 (Phosphopantetheine attachment site) in Meromycolate extension acyl carrier protein. Showing 1 copy in chain C [auth P].

InterPro InterPro annotations
IPR009081
Domain description: Phosphopantetheine binding ACP domain
Occurring in:
  1. Meromycolate extension acyl carrier protein
IPR003231
Domain description: Acyl carrier protein
Occurring in:
  1. Meromycolate extension acyl carrier protein
IPR036736
Domain description: ACP-like superfamily
Occurring in:
  1. Meromycolate extension acyl carrier protein
IPR042486
Domain description: Arabinosyltransferase, C-terminal, subdomain 2
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
IPR032731
Domain description: Arabinosyltransferase, C-terminal
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
IPR007680
Domain description: Arabinofuranosyltransferase, central domain
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
IPR040920
Domain description: Arabinosyltransferas, concanavalin like domain
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A
IPR027451
Domain description: Arabinofuranosyltransferase, domain 1
Occurring in:
  1. Probable arabinosyltransferase B
  2. Probable arabinosyltransferase A

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