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Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol

Electron Microscopy
2.9Å resolution
PDB entry 7bvc coloured by chain, front view.
PDB entry 7bvc coloured by chain, side view.
PDB entry 7bvc coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 86313.56 Å2
Buried surface area: 12134.88 Å2
Dissociation area: 880.81 Å2
Dissociation energy (ΔGdiss): -2.34 kcal/mol
Dissociation entropy (TΔSdiss): 11.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-106399

Macromolecules

Probable arabinosyltransferase B
Chain: A
Length: 1088 amino acids
Theoretical weight: 116.56 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R613 (Residues: 1-1080; Coverage: 100%)
Gene name: MSMEG_6388
Pfam:
InterPro:
Probable arabinosyltransferase B in PDB entry 7bvc, assembly 1, front view.
Probable arabinosyltransferase B in PDB entry 7bvc, assembly 1, side view.
Probable arabinosyltransferase B in PDB entry 7bvc, assembly 1, top view.
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Probable arabinosyltransferase A
Chain: B
Length: 1100 amino acids
Theoretical weight: 119.08 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R614 (Residues: 1-1082; Coverage: 100%)
Gene name: MSMEG_6389
Pfam:
InterPro:
Probable arabinosyltransferase A in PDB entry 7bvc, assembly 1, front view.
Probable arabinosyltransferase A in PDB entry 7bvc, assembly 1, side view.
Probable arabinosyltransferase A in PDB entry 7bvc, assembly 1, top view.
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Meromycolate extension acyl carrier protein
Chain: P
Length: 99 amino acids
Theoretical weight: 10.74 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R0B3 (Residues: 1-99; Coverage: 100%)
Gene names: MSMEG_4326, MSMEI_4226, acpM
Pfam: Phosphopantetheine attachment site
InterPro:
Meromycolate extension acyl carrier protein in PDB entry 7bvc, assembly 1, front view.
Meromycolate extension acyl carrier protein in PDB entry 7bvc, assembly 1, side view.
Meromycolate extension acyl carrier protein in PDB entry 7bvc, assembly 1, top view.
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