› 7c7s

Electron Microscopy
2.9Å resolution

Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.

Released:
DOI: 10.2210/pdb7c7s/pdb
PDB entry 7c7s coloured by chain, front view.
PDB entry 7c7s coloured by chain, side view.
PDB entry 7c7s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of inactive and active GABAB receptor.
Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y
Cell Res 30 564-573 (2020)
PMID: 32494023
Related structures: EMD-30301

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131164 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-aminobutyric acid type B receptor subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 937 amino acids
Theoretical weight: 105.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UBS5 (Residues: 15-919; Coverage: 96%)
  • Best match: Q9UBS5-4 (Residues: 15-904)
Gene names: GABBR1, GPRC3A
Sequence domains:
Gamma-aminobutyric acid type B receptor subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 808 amino acids
Theoretical weight: 91.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75899 (Residues: 41-819; Coverage: 86%)
Gene names: GABBR2, GPR51, GPRC3B
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 8 x NAG
Ligand 2BV 1 x 2BV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-30301
Expression system: Homo sapiens

Quick links

Citations

14 review citations

GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors.
Cerne et al. (2022)
13 more

8 mentions without citation

New insights into GPCR coupling and dimerisation from cryo-EM structures.
Gusach et al. (2023)
7 more