PDB 7c7s biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

Download 3D Visualisation

Assembly Name: GABA-B receptor complex
hide full assembly name

Multimeric state: hetero dimer

Accessible surface area: 64198.99 Å²

Buried surface area: 3720.11 Å²

Dissociation area: 1,038.51 Å²

Dissociation energy (ΔG^diss): 5.59 kcal/mol

Dissociation entropy (TΔS^diss): 15.72 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-131164

Complex Portal ID: CPX-2955

$Hetero dimeric assembly 1 of PDB entry 7c7s coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 1;</li> <li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 2;</li> <li class='image_legend_li'>8 copies of 2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid.</li></ul>}$

$Hetero dimeric assembly 1 of PDB entry 7c7s coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 1;</li> <li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 2;</li> <li class='image_legend_li'>8 copies of 2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid.</li></ul>}$

$Hetero dimeric assembly 1 of PDB entry 7c7s coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 1;</li> <li class='image_legend_li'>1 copy of Gamma-aminobutyric acid type B receptor subunit 2;</li> <li class='image_legend_li'>8 copies of 2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid.</li></ul>}$

Error: API request failed!

Macromolecules

Gamma-aminobutyric acid type B receptor subunit 1

Chain: A
Length: 937 amino acids
Theoretical weight: 105.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: Q9UBS5 (Residues: 15-919; Coverage: 96%)
Best match: Q9UBS5-4 (Residues: 15-904)

Gene names: GABBR1, GPRC3A
Pfam:

Sushi repeat (SCR repeat)
Receptor family ligand binding region
7 transmembrane sweet-taste receptor of 3 GCPR

InterPro:

Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily
GPCR family 3, GABA-B receptor
Periplasmic binding protein-like I
Receptor, ligand binding region
GPCR family 3, C-terminal
GPCR family 3, gamma-aminobutyric acid receptor, type B1

Gamma-aminobutyric acid type B receptor subunit 1 in PDB entry 7c7s, assembly 1, front view.

Gamma-aminobutyric acid type B receptor subunit 1 in PDB entry 7c7s, assembly 1, side view.

Gamma-aminobutyric acid type B receptor subunit 1 in PDB entry 7c7s, assembly 1, top view.

FASTA Sequence


    >pdb|7c7s|A

MKTIIALSYIFCLVFAPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRLEVLFQGPHHHHHHHH

PDBe-KB: UniProt Coverage View: Q9UBS5

View region

From

highlight-only

Hide sections

	UniProt
	Chains
	Domains
	Secondary structure
	Flexibility predictions
	Ligand binding sites
	Interaction interfaces
	Sequence conservation

UniProt

Q9UBS5

Mapping to UniProt GABR1_HUMAN

Chains

Chain A

Domains

Residues mapped to InterPro annotations

Secondary structure

Residues forming Helix

Residues forming Strand

Flexibility predictions

Consensus disorder prediction

Flexibility predictions

Ligand binding sites

Residues binding (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/2BV_200.svg" />

Residues binding 2-acetamido-2-deoxy-beta-D-glucopyranose <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NAG_200.svg" />

Interaction interfaces

Residues interacting with Gamma-aminobutyric acid type B receptor subunit 2 (O75899)

Sequence conservation

Amino acid probabilities The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...

Data displayed by

Property

Probability

Download MSA Click to download the multiple sequence alignment (MSA) file

Amino acid properties

Aromatic

Polar

Hydrophobic

Negative charge

Proline

Positive charge

Cysteine

Glycine

Variants

Filter Consequence

Likely disease

Predicted deleteriousPredicted benign

Likely benign

Uncertain

Filter Provenance

UniProt reviewed

ClinVar reviewed

Large scale studies

FoldX analysis

Missense3D

Observed in PDB

SKEMPI

FireProtDB

Frustratometer

neXtProt

Molecule details ›

Download

FASTA (Protein chains A)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST Q9UBS5 (UniProt)

Gamma-aminobutyric acid type B receptor subunit 2

Chain: B
Length: 808 amino acids
Theoretical weight: 91.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: O75899 (Residues: 41-819; Coverage: 86%)

Gene names: GABBR2, GPR51, GPRC3B
Pfam:

Receptor family ligand binding region
7 transmembrane sweet-taste receptor of 3 GCPR
Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain

InterPro:

GPCR family 3, GABA-B receptor
Periplasmic binding protein-like I
Receptor, ligand binding region
GPCR family 3, C-terminal
GPCR family 3, gamma-aminobutyric acid receptor, type B2
GPCR, family 3
GPCR, family 3, conserved site
Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain

Gamma-aminobutyric acid type B receptor subunit 2 in PDB entry 7c7s, assembly 1, front view.

Gamma-aminobutyric acid type B receptor subunit 2 in PDB entry 7c7s, assembly 1, side view.

Gamma-aminobutyric acid type B receptor subunit 2 in PDB entry 7c7s, assembly 1, top view.

FASTA Sequence


    >pdb|7c7s|B

MKTIIALSYIFCLVFADYKDDDDKGSGGSGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDT

PDBe-KB: UniProt Coverage View: O75899

View region

From

highlight-only

Hide sections

	UniProt
	Chains
	Domains
	Secondary structure
	Flexibility predictions
	Ligand binding sites
	Interaction interfaces
	Sequence conservation

UniProt

O75899

Mapping to UniProt GABR2_HUMAN

Chains

Chain B

Domains

Residues mapped to InterPro annotations

Secondary structure

Residues forming Helix

Residues forming Strand

Flexibility predictions

Consensus disorder prediction

Flexibility predictions

Ligand binding sites

Interaction interfaces

Residues interacting with Gamma-aminobutyric acid type B receptor subunit 1 (Q9UBS5)

Sequence conservation

Amino acid probabilities The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...

Data displayed by

Property

Probability

Download MSA Click to download the multiple sequence alignment (MSA) file

Amino acid properties

Aromatic

Polar

Hydrophobic

Negative charge

Proline

Positive charge

Cysteine

Glycine

Variants

Filter Consequence

Likely disease

Predicted deleteriousPredicted benign

Likely benign

Uncertain

Filter Provenance

UniProt reviewed

ClinVar reviewed

Large scale studies

FoldX analysis

Missense3D

Observed in PDB

SKEMPI

FireProtDB

Frustratometer

neXtProt

Molecule details ›

Download

FASTA (Protein chains B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST O75899 (UniProt)

Protein Data Bank in Europe

Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.

Quick links

Assemblies

Assembly 1 (preferred)

Macromolecules

Filter Consequence

Filter Provenance

Search similar proteins

Filter Consequence

Filter Provenance

Search similar proteins

Quick links

PDBe › 7c7s › Structure analysis

Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.

Quick links

Assemblies

Assembly 1 (preferred)

Macromolecules

Filter Consequence

Filter Provenance

Search similar proteins

Filter Consequence

Filter Provenance

Search similar proteins

Quick links

7c7s › Structure analysis