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The structure of the actin filament uncapping complex mediated by twinfilin

X-ray diffraction
3.2Å resolution
PDB entry 7ccc coloured by chain, front view.
PDB entry 7ccc coloured by chain, side view.
PDB entry 7ccc coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 63499.01 Å2
Buried surface area: 24045.59 Å2
Dissociation area: 3,489.12 Å2
Dissociation energy (ΔGdiss): 13.83 kcal/mol
Dissociation entropy (TΔSdiss): 15.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155649

Macromolecules

Actin, alpha skeletal muscle
Chains: A, E
Length: 377 amino acids
Theoretical weight: 42.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 1-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Pfam: Actin
InterPro:
Actin, alpha skeletal muscle in PDB entry 7ccc, assembly 1, front view.
Actin, alpha skeletal muscle in PDB entry 7ccc, assembly 1, side view.
Actin, alpha skeletal muscle in PDB entry 7ccc, assembly 1, top view.
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Twinfilin-1
Chain: B
Length: 350 amino acids
Theoretical weight: 40.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12792 (Residues: 1-350; Coverage: 100%)
Gene names: PTK9, TWF1
Pfam: Cofilin/tropomyosin-type actin-binding protein
InterPro:
Twinfilin-1 in PDB entry 7ccc, assembly 1, front view.
Twinfilin-1 in PDB entry 7ccc, assembly 1, side view.
Twinfilin-1 in PDB entry 7ccc, assembly 1, top view.
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F-actin-capping protein subunit alpha-1
Chain: C
Length: 286 amino acids
Theoretical weight: 32.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47753 (Residues: 1-286; Coverage: 100%)
Gene names: Cappa1, Capza1
Pfam: F-actin capping protein alpha subunit
InterPro:
F-actin-capping protein subunit alpha-1 in PDB entry 7ccc, assembly 1, front view.
F-actin-capping protein subunit alpha-1 in PDB entry 7ccc, assembly 1, side view.
F-actin-capping protein subunit alpha-1 in PDB entry 7ccc, assembly 1, top view.
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F-actin-capping protein subunit beta
Chain: D
Length: 272 amino acids
Theoretical weight: 30.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q923G3 (Residues: 1-272; Coverage: 100%)
Gene name: Capzb
Pfam: F-actin capping protein, beta subunit
InterPro:
F-actin-capping protein subunit beta in PDB entry 7ccc, assembly 1, front view.
F-actin-capping protein subunit beta in PDB entry 7ccc, assembly 1, side view.
F-actin-capping protein subunit beta in PDB entry 7ccc, assembly 1, top view.
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