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Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex

Electron Microscopy
3.54Å resolution
PDB entry 7ckx coloured by chain, front view.
PDB entry 7ckx coloured by chain, side view.
PDB entry 7ckx coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 41116.96 Å2
Buried surface area: 14999.27 Å2
Dissociation area: 1,646.34 Å2
Dissociation energy (ΔGdiss): 0.42 kcal/mol
Dissociation entropy (TΔSdiss): 12.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210822

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 394 amino acids
Theoretical weight: 45.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 100%)
  • Best match: P63092-4 (Residues: 1-395)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7ckx, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7ckx, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7ckx, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 356 amino acids
Theoretical weight: 39.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7ckx, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7ckx, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7ckx, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7ckx, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7ckx, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7ckx, assembly 1, top view.
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Nanobody 35
Chain: N
Length: 156 amino acids
Theoretical weight: 16.93 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
Nanobody 35 in PDB entry 7ckx, assembly 1, front view.
Nanobody 35 in PDB entry 7ckx, assembly 1, side view.
Nanobody 35 in PDB entry 7ckx, assembly 1, top view.
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D(1A) dopamine receptor
Chain: R
Length: 453 amino acids
Theoretical weight: 50.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21728 (Residues: 1-446; Coverage: 100%)
Gene name: DRD1
Pfam: 7 transmembrane receptor (rhodopsin family)
InterPro:
D(1A) dopamine receptor in PDB entry 7ckx, assembly 1, front view.
D(1A) dopamine receptor in PDB entry 7ckx, assembly 1, side view.
D(1A) dopamine receptor in PDB entry 7ckx, assembly 1, top view.
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