› 7cm5

Electron Microscopy
2.6Å resolution

Full-length Sarm1 in a self-inhibited state

Released:
DOI: 10.2210/pdb7cm5/pdb
PDB entry 7cm5 coloured by chain, front view.
PDB entry 7cm5 coloured by chain, side view.
PDB entry 7cm5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z
Nature 588 658-663 (2020)
PMID: 33053563
Related structures: EMD-30401

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 733 amino acids
Theoretical weight: 80.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6SZW1 (Residues: 1-724; Coverage: 100%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-30401
Expression system: Homo sapiens

Quick links

Citations

27 review citations

The landscape of aging.
Cai et al. (2022)
26 more

1 mention without citation

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Loreto et al. (2021)