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Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide

X-ray diffraction
1.6Å resolution
PDB entry 7cna coloured by chain, front view.
PDB entry 7cna coloured by chain, side view.
PDB entry 7cna coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 24479.38 Å2
Buried surface area: 10874.67 Å2
Dissociation area: 212.04 Å2
Dissociation energy (ΔGdiss): -10.18 kcal/mol
Dissociation entropy (TΔSdiss): 12.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-168125

Macromolecules

Spindlin-1
Chains: A, D
Length: 212 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y657 (Residues: 51-262; Coverage: 81%)
Gene names: OCR, SPIN, SPIN1
Pfam: Spin/Ssty Family
InterPro:
Spindlin-1 in PDB entry 7cna, assembly 1, front view.
Spindlin-1 in PDB entry 7cna, assembly 1, side view.
Spindlin-1 in PDB entry 7cna, assembly 1, top view.
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Spindlin interactor and repressor of chromatin-binding protein
Chains: B, E
Length: 30 amino acids
Theoretical weight: 3.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUA3 (Residues: 254-283; Coverage: 8%)
Gene names: C11orf84, SPINDOC
Spindlin interactor and repressor of chromatin-binding protein in PDB entry 7cna, assembly 1, front view.
Spindlin interactor and repressor of chromatin-binding protein in PDB entry 7cna, assembly 1, side view.
Spindlin interactor and repressor of chromatin-binding protein in PDB entry 7cna, assembly 1, top view.
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ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR
Chain: C
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: synthetic construct
Expression system: Not provided
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR in PDB entry 7cna, assembly 1, front view.
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR in PDB entry 7cna, assembly 1, side view.
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR in PDB entry 7cna, assembly 1, top view.
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ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY
Chain: F
Length: 12 amino acids
Theoretical weight: 1.35 KDa
Source organism: synthetic construct
Expression system: Not provided
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY in PDB entry 7cna, assembly 1, front view.
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY in PDB entry 7cna, assembly 1, side view.
ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY in PDB entry 7cna, assembly 1, top view.
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