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human KCNQ2-CaM in apo state

Electron Microscopy
3.6Å resolution
PDB entry 7cr3 coloured by chain, front view.
PDB entry 7cr3 coloured by chain, side view.
PDB entry 7cr3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calmodulin-3 and Potassium voltage-gated channel subfamily KQT member 2
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Multimeric state: hetero octamer
Accessible surface area: 97690.49 Å2
Buried surface area: 41895.9 Å2
Dissociation area: 9,967.26 Å2
Dissociation energy (ΔGdiss): 141.38 kcal/mol
Dissociation entropy (TΔSdiss): 54.36 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-128989

Macromolecules

Potassium voltage-gated channel subfamily KQT member 2
Chains: A, B, D, G
Length: 656 amino acids
Theoretical weight: 73.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43526 (Residues: 64-702; Coverage: 73%)
Gene name: KCNQ2
Pfam:
InterPro:
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 7cr3, assembly 1, front view.
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 7cr3, assembly 1, side view.
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 7cr3, assembly 1, top view.
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Search similar proteins

Calmodulin-3
Chains: C, E, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0DP25 (Residues: 1-149; Coverage: 100%)
Gene names: CALM3, CALML2, CAM3, CAMC, CAMIII
Pfam: EF-hand domain pair
InterPro:
Calmodulin-3 in PDB entry 7cr3, assembly 1, front view.
Calmodulin-3 in PDB entry 7cr3, assembly 1, side view.
Calmodulin-3 in PDB entry 7cr3, assembly 1, top view.
Molecule details ›

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