› 7csk

Solution NMR

A 2:1 stoichiometric complex of anticancer drug Adriamycin bound to parallel G-quadruplex DNA [d-(TTGGGGT)]4.

Released:
DOI: 10.2210/pdb7csk/pdb
PDB entry 7csk coloured by chain, ensemble of 10 models, front view.
PDB entry 7csk coloured by chain, ensemble of 10 models, side view.
PDB entry 7csk coloured by chain, ensemble of 10 models, top view.
Source organism: Tetrahymena thermophila
Entry authors: Barthwal R, Tariq Z, Pandav K

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-121174 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 7 nucleotides
Theoretical weight: 2.18 KDa
Source organism: Tetrahymena thermophila
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM2 2 x DM2
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 12%
Refinement method: simulated annealing
Expression system: Not provided

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