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A 2:1 stoichiometric complex of anticancer drug Adriamycin bound to parallel G-quadruplex DNA [d-(TTGGGGT)]4.

Solution NMR
PDB entry 7csk coloured by chain, ensemble of 10 models, front view.
PDB entry 7csk coloured by chain, ensemble of 10 models, side view.
PDB entry 7csk coloured by chain, ensemble of 10 models, top view.
Source organism: Tetrahymena thermophila
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA
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Multimeric state: homo tetramer
Accessible surface area: 4466.19 Å2
Buried surface area: 5072.58 Å2
Dissociation area: 2,035.8 Å2
Dissociation energy (ΔGdiss): 0.83 kcal/mol
Dissociation entropy (TΔSdiss): 18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-121174

Macromolecules

DNA chains A, B, C, D
Name: DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3')
Representative chains: A, B, C, D
Source organism: Tetrahymena thermophila [5911]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.18 KDa
DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3') in PDB entry 7csk, assembly 1, front view.
DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3') in PDB entry 7csk, assembly 1, side view.
DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3') in PDB entry 7csk, assembly 1, top view.
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