› › Structure analysis

Crystal structure of PDE8A catalytic domain in complex with 3a

X-ray diffraction
2.8Å resolution
PDB entry 7cwg coloured by chain, front view.
PDB entry 7cwg coloured by chain, side view.
PDB entry 7cwg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 15301.98 Å2
Buried surface area: 249.85 Å2
Dissociation area: 78.24 Å2
Dissociation energy (ΔGdiss): 17.9 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130049

Macromolecules

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Chain: A
Length: 338 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60658 (Residues: 482-819; Coverage: 41%)
Gene name: PDE8A
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7cwg, assembly 1, front view.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7cwg, assembly 1, side view.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7cwg, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links