› 7cyn

Electron Microscopy
4.2Å resolution

Cryo-EM structure of human TLR7 in complex with UNC93B1

Released:
DOI: 10.2210/pdb7cyn/pdb
PDB entry 7cyn coloured by chain, front view.
PDB entry 7cyn coloured by chain, side view.
PDB entry 7cyn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol 28 173-180 (2021)
PMID: 33432245
Related structures: EMD-30501

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190511 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Toll-like receptor 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1049 amino acids
Theoretical weight: 121.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NYK1 (Residues: 1-1049; Coverage: 100%)
Gene names: TLR7, UNQ248/PRO285
Sequence domains:
Protein unc-93 homolog B1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 597 amino acids
Theoretical weight: 66.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1C4 (Residues: 1-597; Coverage: 100%)
Gene names: UNC93, UNC93B, UNC93B1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-30501
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Regulation of the nucleic acid-sensing Toll-like receptors.
Lind et al. (2022)
7 more

12 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
11 more