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Cryo-EM structure of human TLR7 in complex with UNC93B1

Electron Microscopy
4.2Å resolution
PDB entry 7cyn coloured by chain, front view.
PDB entry 7cyn coloured by chain, side view.
PDB entry 7cyn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Toll-like receptor 7 and Protein unc-93 homolog B1
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Multimeric state: hetero tetramer
Accessible surface area: 114274.28 Å2
Buried surface area: 6810.78 Å2
Dissociation area: 255.8 Å2
Dissociation energy (ΔGdiss): -17.51 kcal/mol
Dissociation entropy (TΔSdiss): 17.31 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190511

Macromolecules

Toll-like receptor 7
Chains: A, B
Length: 1049 amino acids
Theoretical weight: 121.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NYK1 (Residues: 1-1049; Coverage: 100%)
Gene names: TLR7, UNQ248/PRO285
Pfam:
InterPro:
Toll-like receptor 7 in PDB entry 7cyn, assembly 1, front view.
Toll-like receptor 7 in PDB entry 7cyn, assembly 1, side view.
Toll-like receptor 7 in PDB entry 7cyn, assembly 1, top view.
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Protein unc-93 homolog B1
Chains: C, D
Length: 597 amino acids
Theoretical weight: 66.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1C4 (Residues: 1-597; Coverage: 100%)
Gene names: UNC93, UNC93B, UNC93B1
InterPro: Protein unc-93 homolog B1
Protein unc-93 homolog B1 in PDB entry 7cyn, assembly 1, front view.
Protein unc-93 homolog B1 in PDB entry 7cyn, assembly 1, side view.
Protein unc-93 homolog B1 in PDB entry 7cyn, assembly 1, top view.
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