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HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.

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Xiao Y, Li W, Yang H, Pan L, Zhang L, Lu L, Chen J, Wei W, Ye J, Li J, Li G, Zhang Y, Tan M, Ding J, Wong J
OpenAccess logo Nucleic Acids Res 49 8037-8059 (2021)
Related entries: 7d0o, 7d0q, 7d0r, 7d0s

Cited: 14 times
EuropePMC logo PMID: 34259319

Abstract

Recent studies demonstrate that histones are subjected to a series of short-chain fatty acid modifications that is known as histone acylations. However, the enzymes responsible for histone acylations in vivo are not well characterized. Here, we report that HBO1 is a versatile histone acyltransferase that catalyzes not only histone acetylation but also propionylation, butyrylation and crotonylation both in vivo and in vitro and does so in a JADE or BRPF family scaffold protein-dependent manner. We show that the minimal HBO1/BRPF2 complex can accommodate acetyl-CoA, propionyl-CoA, butyryl-CoA and crotonyl-CoA. Comparison of CBP and HBO1 reveals that they catalyze histone acylations at overlapping as well as distinct sites, with HBO1 being the key enzyme for H3K14 acylations. Genome-wide chromatin immunoprecipitation assay demonstrates that HBO1 is highly enriched at and contributes to bulk histone acylations on the transcriptional start sites of active transcribed genes. HBO1 promoter intensity highly correlates with the level of promoter histone acylation, but has no significant correlation with level of transcription. We also show that HBO1 is associated with a subset of DNA replication origins. Collectively our study establishes HBO1 as a versatile histone acyltransferase that links histone acylations to promoter acylations and selection of DNA replication origins.

Articles - 7d0p mentioned but not cited (1)

  1. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Xiao Y, Li W, Yang H, Pan L, Zhang L, Lu L, Chen J, Wei W, Ye J, Li J, Li G, Zhang Y, Tan M, Ding J, Wong J. Nucleic Acids Res 49 8037-8059 (2021)


Reviews citing this publication (7)

  1. Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification. Fu Y, Yu J, Li F, Ge S. J Exp Clin Cancer Res 41 144 (2022)
  2. Lysine Crotonylation: An Emerging Player in DNA Damage Response. Zhao Y, Hao S, Wu W, Li Y, Hou K, Liu Y, Cui W, Xu X, Wang H. Biomolecules 12 1428 (2022)
  3. Post-translational modifications of histones: Mechanisms, biological functions, and therapeutic targets. Liu R, Wu J, Guo H, Yao W, Li S, Lu Y, Jia Y, Liang X, Tang J, Zhang H. MedComm (2020) 4 e292 (2023)
  4. DNA replication: Mechanisms and therapeutic interventions for diseases. Song HY, Shen R, Mahasin H, Guo YN, Wang DG. MedComm (2020) 4 e210 (2023)
  5. Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases. Xue Q, Yang Y, Li H, Li X, Zou L, Li T, Ma H, Qi H, Wang J, Yu T. Genes Dis 10 2479-2490 (2023)
  6. Protein lysine four-carbon acylations in health and disease. Fang Y, Li X. J Cell Physiol (2023)
  7. The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review. Xu J, Li C, Kang X. Front Physiol 14 1267456 (2023)

Articles citing this publication (6)

  1. HBO1 catalyzes lysine benzoylation in mammalian cells. Tan D, Wei W, Han Z, Ren X, Yan C, Qi S, Song X, Zheng YG, Wong J, Huang H. iScience 25 105443 (2022)
  2. Legionella para-effectors target chromatin and promote bacterial replication. Schator D, Mondino S, Berthelet J, Di Silvestre C, Ben Assaya M, Rusniok C, Rodrigues-Lima F, Wehenkel A, Buchrieser C, Rolando M. Nat Commun 14 2154 (2023)
  3. Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma. Bitler BG, Bailey CA, Yamamoto TM, McMellen A, Kim H, Watson ZL. Mol Carcinog 62 1717-1730 (2023)
  4. HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis. Xing B, Lan H, Li H. Oxid Med Cell Longev 2022 1881519 (2022)
  5. HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation. Li J, Lu L, Liu L, Ren X, Chen J, Yin X, Xiao Y, Li J, Wei G, Huang H, Wei W, Wong J. Cell Discov 9 85 (2023)
  6. Molecular Characteristics and Therapeutic Vulnerabilities of Claudin-low Breast Cancers Derived from Cell Line Models. Voutsadakis IA. Cancer Genomics Proteomics 20 539-555 (2023)


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