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Structure of human TRPC5 in complex with HC-070

Electron Microscopy
2.74Å resolution
PDB entry 7d4q coloured by chain, front view.
PDB entry 7d4q coloured by chain, side view.
PDB entry 7d4q coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Short transient receptor potential channel 5
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Multimeric state: homo tetramer
Accessible surface area: 120448.68 Å2
Buried surface area: 46460.97 Å2
Dissociation area: 20,904.81 Å2
Dissociation energy (ΔGdiss): 299.43 kcal/mol
Dissociation entropy (TΔSdiss): 53.36 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-193913

Macromolecules

Short transient receptor potential channel 5
Chains: A, B, C, D
Length: 764 amino acids
Theoretical weight: 88.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UL62 (Residues: 1-764; Coverage: 79%)
Gene names: TRP5, TRPC5
Pfam:
InterPro:
Short transient receptor potential channel 5 in PDB entry 7d4q, assembly 1, front view.
Short transient receptor potential channel 5 in PDB entry 7d4q, assembly 1, side view.
Short transient receptor potential channel 5 in PDB entry 7d4q, assembly 1, top view.
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