› 7d4q

Electron Microscopy
2.74Å resolution

Structure of human TRPC5 in complex with HC-070

Released:
DOI: 10.2210/pdb7d4q/pdb
PDB entry 7d4q coloured by chain, front view.
PDB entry 7d4q coloured by chain, side view.
PDB entry 7d4q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
Elife 10 (2021)
PMID: 33683200
Related structures: EMD-30576

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 764 amino acids
Theoretical weight: 88.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UL62 (Residues: 1-764; Coverage: 79%)
Gene names: TRP5, TRPC5
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand PTY 4 x PTY
Ligand POV 4 x POV
Ligand Y01 4 x Y01
Ligand ZN 4 x ZN
Ligand CA 4 x CA
Ligand GWR 4 x GWR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.74Å
Relevant EMDB volumes: EMD-30576
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
6 more

2 mentions without citation

Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking.
Shim et al. (2022)
1 more