› 7dsc

Electron Microscopy
3.5Å resolution

CALHM1 open state with disordered CTH

Released:
DOI: 10.2210/pdb7dsc/pdb
PDB entry 7dsc coloured by chain, front view.
PDB entry 7dsc coloured by chain, side view.
PDB entry 7dsc coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.
Ren Y, Li Y, Wang Y, Wen T, Lu X, Chang S, Zhang X, Shen Y, Yang X
J Biol Chem 298 101838 (2022)
PMID: 35339491
Related structures: EMD-30830

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 358 amino acids
Theoretical weight: 41.21 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: E7F2J4 (Residues: 2-346; Coverage: 100%)
Gene name: calhm1a
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-30830
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Contribution of large-pore channels to inflammation induced by microorganisms.
Vega et al. (2022)
1 more

1 mention without citation

Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.
Ren et al. (2022)