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CALHM1 open state with disordered CTH

Electron Microscopy
3.5Å resolution
PDB entry 7dsc coloured by chain, front view.
PDB entry 7dsc coloured by chain, side view.
PDB entry 7dsc coloured by chain, top view.
Source organism: Danio rerio
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calcium homeostasis modulator protein 1
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Multimeric state: homo octamer
Accessible surface area: 84004.14 Å2
Buried surface area: 21392.21 Å2
Dissociation area: 9,647.2 Å2
Dissociation energy (ΔGdiss): 108.21 kcal/mol
Dissociation entropy (TΔSdiss): 95.79 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-123070

Macromolecules

Calcium homeostasis modulator protein 1
Chains: A, B, C, D, E, F, G, H
Length: 358 amino acids
Theoretical weight: 41.21 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: E7F2J4 (Residues: 2-346; Coverage: 100%)
Gene name: calhm1a
Pfam: Calcium homeostasis modulator
InterPro: Calcium homeostasis modulator family
Calcium homeostasis modulator 1 in PDB entry 7dsc, assembly 1, front view.
Calcium homeostasis modulator 1 in PDB entry 7dsc, assembly 1, side view.
Calcium homeostasis modulator 1 in PDB entry 7dsc, assembly 1, top view.
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