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Crystal structure of human Proto-oncogene tyrosine-protein kinase receptor Ret in complex with 4-amino-7-(1-methylcyclopropyl)-N-(5-methyl-1H-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide

X-ray diffraction
1.64Å resolution
PDB entry 7dua coloured by chain, front view.
PDB entry 7dua coloured by chain, side view.
PDB entry 7dua coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble RET kinase fragment
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Multimeric state: homo dimer
Accessible surface area: 24930.76 Å2
Buried surface area: 2683.12 Å2
Dissociation area: 1,341.56 Å2
Dissociation energy (ΔGdiss): 7.76 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-139854

Macromolecules

Soluble RET kinase fragment
Chains: A, B
Length: 314 amino acids
Theoretical weight: 35.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07949 (Residues: 705-1013; Coverage: 29%)
Gene names: CDHF12, CDHR16, PTC, RET
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Soluble RET kinase fragment in PDB entry 7dua, assembly 1, front view.
Soluble RET kinase fragment in PDB entry 7dua, assembly 1, side view.
Soluble RET kinase fragment in PDB entry 7dua, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P07949  
131420406080100120140160180200220240260280300
 
100200300
UniProt
P07949
PRO_0000415292
PRO_0000415293
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