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Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.

Wang Y, Zhou X, Luo J, Lv S, Liu R, Du X, Jia B, Yuan F, Zhang H, Du J
J Integr Plant Biol 63 1091-1096 (2021)
Related entries: 7eez, 7ef1, 7ef2, 7ef3

Cited: 4 times
EuropePMC logo PMID: 33913587

Abstract

RNA-directed DNA methylation (RdDM) is a plant-specific de novo DNA methylation pathway, which has extensive cross-talk with histone modifications. Here, we report that the maize RdDM regulator SAWADEE HOMEODOMAIN HOMOLOG 2 (SHH2) is an H3K9me1 reader. Our structural studies reveal that H3K9me1 recognition is achieved by recognition of the methyl group via a classic aromatic cage and hydrogen-bonding and salt-bridge interactions with the free protons of the mono-methyllysine. The di- and tri-methylation states disrupt the polar interactions, decreasing the binding affinity. Our study reveals a mono-methyllysine recognition mechanism which potentially links RdDM to H3K9me1 in maize.

Reviews citing this publication (1)

  1. Reprogramming of Histone H3 Lysine Methylation During Plant Sexual Reproduction. Fang H, Shao Y, Wu G. Front Plant Sci 12 782450 (2021)

Articles citing this publication (3)

  1. The TRIPLE PHD FINGERS proteins are required for SWI/SNF complex-mediated +1 nucleosome positioning and transcription start site determination in Arabidopsis. Diego-Martin B, Pérez-Alemany J, Candela-Ferre J, Corbalán-Acedo A, Pereyra J, Alabadí D, Jami-Alahmadi Y, Wohlschlegel J, Gallego-Bartolomé J. Nucleic Acids Res 50 10399-10417 (2022)
  2. DNA cytosine methylation dynamics and functional roles in horticultural crops. Liu P, Liu R, Xu Y, Zhang C, Niu Q, Lang Z. Hortic Res 10 uhad170 (2023)
  3. Structure and Mechanism of Plant DNA Methyltransferases. Leichter SM, Du J, Zhong X. Adv Exp Med Biol 1389 137-157 (2022)


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