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Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form II)

X-ray diffraction
1.97Å resolution
PDB entry 7ef9 coloured by chain, front view.
PDB entry 7ef9 coloured by chain, side view.
PDB entry 7ef9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenine DNA glycosylase and DNA
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Multimeric state: hetero trimer
Accessible surface area: 23584.97 Å2
Buried surface area: 7128.23 Å2
Dissociation area: 1,887.8 Å2
Dissociation energy (ΔGdiss): 16.16 kcal/mol
Dissociation entropy (TΔSdiss): 11.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-511489

Macromolecules

Adenine DNA glycosylase
Chain: A
Length: 448 amino acids
Theoretical weight: 50.11 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99P21 (Residues: 45-487; Coverage: 86%)
Gene names: Mutyh, Myh
Pfam:
InterPro:
Adenine DNA glycosylase in PDB entry 7ef9, assembly 1, front view.
Adenine DNA glycosylase in PDB entry 7ef9, assembly 1, side view.
Adenine DNA glycosylase in PDB entry 7ef9, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*AP*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3')
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.39 KDa
DNA (5'-D(*AP*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3') in PDB entry 7ef9, assembly 1, front view.
DNA (5'-D(*AP*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3') in PDB entry 7ef9, assembly 1, side view.
DNA (5'-D(*AP*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3') in PDB entry 7ef9, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3')
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.08 KDa
DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3') in PDB entry 7ef9, assembly 1, front view.
DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3') in PDB entry 7ef9, assembly 1, side view.
DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3') in PDB entry 7ef9, assembly 1, top view.
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